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Hui Huang Bradi R. Lorenz Paula Horn Zelmanovitz Catherine B. Chan 《International journal of molecular sciences》2021,22(1)
Prediabetes is a high-risk condition for type 2 diabetes (T2D). Pancreatic β-cells adapt to impaired glucose regulation in prediabetes by increasing insulin secretion and β-cell mass expansion. In people with prediabetes, metformin has been shown to prevent prediabetes conversion to diabetes. However, emerging evidence indicates that metformin has negative effects on β-cell function and survival. Our previous study established the Nile rat (NR) as a model for prediabetes, recapitulating characteristics of human β-cell compensation in function and mass expansion. In this study, we investigated the action of metformin on β-cells in vivo and in vitro. A 7-week metformin treatment improved glucose tolerance by reducing hepatic glucose output and enhancing insulin secretion. Although high-dose metformin inhibited β-cell glucose-stimulated insulin secretion in vitro, stimulation of β-cell insulin secretion was preserved in metformin-treated NRs via an indirect mechanism. Moreover, β-cells in NRs receiving metformin exhibited increased endoplasmic reticulum (ER) chaperones and alleviated apoptotic unfold protein response (UPR) without changes in the expression of cell identity genes. Additionally, metformin did not suppress β-cell mass compensation or proliferation. Taken together, despite the conflicting role indicated by in vitro studies, administration of metformin does not exert a negative effect on β-cell function or cell mass and, instead, early metformin treatment may help protect β-cells from exhaustion and decompensation. 相似文献
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刀具磨损状态是机械加工过程中需考虑的重要因素之一.针对铣刀磨损的在线预测问题,建立了一种基于深度学习的铣刀磨损预测模型.首先,将采集到的铣刀切削时的振动信号进行小波去噪后,利用快速傅里叶变换和小波包分解等技术提取时域、频域及时频域上的特征参数,并根据相关性分析从中筛选出合格的特征参数合并为特征向量,以此作为堆叠稀疏去噪自动编码网络(SSDAE)的含噪样本.其次,利用特征后处理的方式对已经筛选出的特征参数进行单调不递减及平滑处理,并将其作为SSDAE的无噪样本来训练该网络.然后,将经过SSDAE降维后的特征向量作为多隐层反向传播神经网络(BPNN)的输入,以这些特征对应的实际铣刀的磨损量作为标签对该网络进行拟合训练.最后,对训练好的模型进行实验验证,通过测试数据集和人为加入噪声的测试数据集的对比,结果显示所提模型不仅具有较高的预测精度,还具有较高的鲁棒性. 相似文献
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针对电网存在的暂降、低电压、谐波、无功等电能质量问题,采用一种背靠背式单相三电平无耦合变压器的拓扑结构,与H桥等结构相比,无桥臂之间耦合问题,降低了设备损耗及成本,同时本文整流侧采用TTA算法检测无功电流,具备无功补偿功能.对于逆变侧,采用输出电压前馈控制策略,消除了负载对逆变系统控制性能的影响,同时充分利用设备调制度较小的情况,在DSP中采用立即刷新的方式,消除了控制延时的影响,提高了系统的开环增益、响应速度、稳态控制效果和系统鲁棒性.所研制的10 kVA的补偿设备验证了该拓扑结构、TTA算法及控制方法的正确性和有效性. 相似文献
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Sijia Huo Yujin Wang Mianyi Yao Zhikun Zhang Lei Chen Hui Gu Jiahu Ouyang Yu Zhou 《Journal of the European Ceramic Society》2021,41(11):5466-5473
Novel TiC-based composites were synthesized by reactive hot-pressing at 1800 °C for 1 h with ZrB2 addition as a sintering aid for the first time. The effects of ZrB2 contents on the phase composition, microstructure evolution, and mechanical properties were reported. Based on the reaction and solid solution coupling effects between ZrB2 and TiC, the product ZrC may be partially or completely dissolved into the TiC matrix, and then phase separation within the miscibility gap is observed to form lamellar nanostructured ZrC-rich (Zr, Ti)C. The TiC-10 mol.% ZrB2 (starting batch composition) exhibits good comprehensive mechanical properties of hardness 27.7 ± 1.3 GPa, flexural strength 659 ± 48 MPa, and fracture toughness of 6.5 ± 0.6 MPa m1/2, respectively, which reach or exceed most TiC-based composites using ceramics as sintering aids in the previous reports. 相似文献
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Most protons in the solar wind belong to one of two different populations,the less dense beam protons and the denser core protons.The beam protons,with a velocity of(1-2)VA(VA is the local Alfvén speed),always drift relative to the core protons;this kind of distribution is unstable and stimulates several kinds of wave mode.In this study,using a 2D hybrid simulation model,we find that the original right-handed elliptically polarized Alfvén waves become linearly polarized,and eventually become right-handed and circularly polarized.Given that linearly polarized waves are a superposition of left-handed and right-handed waves,cyclotron resonance in the right-handed/left-handed component heats beam/core protons perpendicularly.The resonance between beam protons and right-handed polarized waves is stronger when the beam relative density is lower,resulting in more dramatic perpendicular heating of beam protons,whereas the situation is reversed when the beam relative density is larger. 相似文献
28.
Mengmeng Sun Xinjian Fan Chenyao Tian Mingxuan Yang Lining Sun Hui Xie 《Advanced functional materials》2021,31(19):2011193
Many astonishing biological collective behaviors exist in nature, and artificial microrobotic swarms have been developed by emulating these scenarios. However, these microswarms typically have single structures and lack the adaptability that many biological swarms exhibit to thrive in complex environments. Inspired by viscoelastic fire ant aggregations and using a combination of experiment and simulation, a strategy to trigger ferrofluid droplets into forming microswarms exhibiting both liquid-like and solid-like behaviors is reported. By spatiotemporally programming an applied magnetic field, microswarms can be liquefied to implement reversible elongation with a high aspect ratio and solidified into entireties to perform overturning and bending behaviors. It is demonstrated that reconfigurability enables the microswarm to be a mobile dexterous micromanipulator, acting not only as a soft “octopus arm” to explore a confined environment and grasp a targeted object but also adaptively navigate multiple terrains, such as uneven surfaces, curved grooves, complex mazes, high steps, narrow channels, and even wide gaps. This microrobotic swarm can reconfigure both shapes and tasks based on the demands of the environment, presenting novel solutions for a variety of applications. 相似文献
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